DVT (deep vein thrombosis) is also commonly called a blood clot in a deep vein and is a real problem that can have a number of risk factors, estrogen use being one of them. I have several of those risk factors, one being age and another being sedentary lifestyle. I do not have a sedentary life but with work I would stay in a driving position for 7-8 hours a day. I also had varicose veins which was a hereditary issue.
After 3 months on 8mg/day of estradiol pills I had a DVT. The danger of that in a deep vein is that it leads back to the right side of the heart and then to the lungs. In the lungs it can cause a pulmonary embolism with symptoms of shortness of breath and possibly death. My does was reduced to 4mg/day and was changed over to patches which are generally considered safer. Patches provide a continuous supply of estrogen and are considered safer since they do not have peaks like pills would.
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