Spiro is a diuretic and is intended to lower blood pressure by elimination of fluid (water) from the blood. Before a person takes Spiro they need a kidney test to ensure good kidney function.
My wife is a nurse practitioner specializing in nephrology (urinary systems). I had to lower the dose of blood pressure medication when I started Spiro because it lowered my blood pressure too far. Maybe that is the reason some have a sense of brain fog. Additionally, Spiro is not an androgen blocker. Lower testosterone is a side effect of the medication. The alternative for taking Spiro is to have the testicles removed; which several of my friends have needed to do that were unable to take Spiro.