My personal experience with spiroloctone is positive. Within 2 months my testosterone levels went from 823 pre hrt level. 2 months later my testosterone is less than 12 and has stayed there for the last 3 months. My estrogen levels have been climbing since the start of hrt, but not at the levels theu should be, however my endo wants to up my dose and switch me to estriadial injectables which generally have a better success rate. Hope that helped, the only side effect is lactic acid buildup in my calves. So had to reduce my pottasium intake to avoid cramps in the calves. Good luck!